Barneys New York was an American luxury department store founded in 1923 in New York City. Barneys was Ana Romero's first major client and their collaboration lasted for seven years, from 2012 up to it's closing in 2019. During this time Barneys represented the brand at the Madison Av., Chicago, Houston and Beverly Hills stores.

In 2015 Ana Romero also designed an exclusive collection for Barneys New York. The XO “Exclusively Ours” collaboration featured Ana’s signature optical prints on home goods and accessories including lacquered trays, boxes, vanity items, pillows and iPhone cases. The collection was available at Barneys Madison Avenue (Nineth Floor, Chelsea Passage) as well as online at Barneys.com.